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  I felt as though I were communing directly with a plant for the first time and that certain ideas I had long thought about and written about—having to do with the subjectivity of other species and the way they act upon us in ways we’re too self-regarding to appreciate—had taken on the flesh of feeling and reality. I looked through the negative spaces formed by the hydrangea leaves to fix my gaze on the swamp maple in the middle of the meadow beyond, and it too was now more alive than I’d ever known a tree to be, infused with some kind of spirit—this one, too, benevolent. The idea that there had ever been a disagreement between matter and spirit seemed risible, and I felt as though whatever it is that usually divides me from the world out there had begun to fall away. Not completely: the battlements of ego had not fallen; this was not what the researchers would deem a “complete” mystical experience, because I retained the sense of an observing I. But the doors and windows of perception had opened wide, and they were admitting more of the world and its myriad nonhuman personalities than ever before.

  Buoyed by this development, I sat up now and looked out over my desk, through the big window that faced back to the house. When I sited the building, I carefully framed the main view between two very old and venerable trees, a stolidly vertical ash on the right and an elegantly angled and intricately branched white oak on the left. The ash has seen better days; storms have shorn several important limbs from it, wrecking its symmetry and leaving some ragged stumps. The oak was somewhat healthier, in full leaf now with its upturned limbs reaching into the sky like the limbs of a dancer. But the main trunk, which had always leaned precariously to one side, now concerned me: a section of it had rotted out at ground level, and for the first time it was possible to look clear through it and see daylight. How was it possibly still standing?

  As I gazed at the two trees I had gazed at so many times before from my desk, it suddenly dawned on me that these trees were—obviously!—my parents: the stolid ash my father, the elegant oak my mother. I don’t know exactly what I mean by that, except that thinking about those trees became identical to thinking about my parents. They were completely, indelibly, present in those trees. And so I thought about all they had given me, and about all that time had done to them, and what was going to become of this prospect, this place (this me!), when they finally fell, as eventually they would. That parents die is not exactly the stuff of epiphany, but the prospect, no longer distant or abstract, pierced me more deeply than it ever had, and I was disarmed yet again by the pervasive sense of poignancy that trailed me all that afternoon. Yet I must have still had some wits about me, because I made a note to call the arborist tomorrow; maybe something could be done to reduce the weight on the leaning side of the oak, in order to prevent it from falling, if only for a while longer.

  My walk back to the house was, I think, the peak of the experience and comes back to me now in the colors and tones of a dream. There was, again, the sense of pushing my body through a mass of air that had been sweetened by phlox and was teeming, almost frenetic, with activity. The dragonflies, big as birds, were now out in force, touching down just long enough to kiss the phlox blossoms and then lift off, before madly crisscrossing the garden path. These were more dragonflies than I had ever seen in one place, so many in fact that I wasn’t completely sure if they were real. (Judith later confirmed the sighting when I got her to come outside.) And as they executed their flight patterns, they left behind them contrails that persisted in the air, or so at least it appeared. Dusk now approaching, the air traffic in the garden had built to a riotous crescendo: the pollinators making their last rounds of the day, the plants still signifying to them with their flowers: me, me, me! In one way I knew this scene well—the garden coming briefly back to life after the heat of a summer day has relented—but never had I felt so integral to it. I was no longer the alienated human observer, gazing at the garden from a distance, whether literal or figural, but rather felt part and parcel of all that was transpiring here. So the flowers were addressing me as much as the pollinators, and perhaps because the very air that afternoon was such a felt presence, one’s usual sense of oneself as a subject observing objects in space—objects that have been thrown into relief and rendered discrete by the apparent void that surrounds them—gave way to a sense of being deep inside and fully implicated in this scene, one more being in relation to the myriad other beings and to the whole.

  “Everything is interaction and reciprocal,” wrote Humboldt, and that felt very much the case, and so, for the first time I can remember, did this: “I myself am identical with nature.”

  * * *

  • • •

  I HONESTLY DON’T KNOW what to make of this experience. In a certain light at certain moments, I feel as though I had had some kind of spiritual experience. I had felt the personhood of other beings in a way I hadn’t before; whatever it is that keeps us from feeling our full implication in nature had been temporarily in abeyance. There had also been, I felt, an opening of the heart, toward my parents, yes, and toward Judith, but also, weirdly, toward some of the plants and trees and birds and even the damn bugs on our property. Some of this openness has persisted. I think back on it now as an experience of wonder and immanence.

  The fact that this transformation of my familiar world into something I can only describe as numinous was occasioned by the eating of a little brown mushroom that Stamets and I had found growing on the edge of a parking lot in a state park on the Pacific coast—well, that fact can be viewed in one of two ways: either as an additional wonder or as support for a more prosaic and materialist interpretation of what happened to me that August afternoon. According to one interpretation, I had had “a drug experience,” plain and simple. It was a kind of waking dream, interesting and pleasurable but signifying nothing. The psilocin in that mushroom unlocked the 5-hydroxytryptamine 2-A receptors in my brain, causing them to fire wildly and set off a cascade of disordered mental events that, among other things, permitted some thoughts and feelings, presumably from my subconscious (and, perhaps, my reading too), to get cross-wired with my visual cortex as it was processing images of the trees and plants and insects in my field of vision.

  Not quite a hallucination, “projection” is probably the psychological term for this phenomenon: when we mix our emotions with certain objects that then reflect those feelings back to us so that they appear to glisten with meaning. T. S. Eliot called these things and situations the “objective correlatives” of human emotion. Emerson had a similar phenomenon in mind when he said that “Nature always wears the colors of the spirit,” suggesting it is our minds that dress her in such significance.

  I’m struck by the fact there was nothing supernatural about my heightened perceptions that afternoon, nothing that I needed an idea of magic or a divinity to explain. No, all it took was another perceptual slant on the same old reality, a lens or mode of consciousness that invented nothing but merely (merely!) italicized the prose of ordinary experience, disclosing the wonder that is always there in a garden or wood, hidden in plain sight—another form of consciousness “parted from [us],” as William James put it, “by the filmiest of screens.” Nature does in fact teem with subjectivities—call them spirits if you like—other than our own; it is only the human ego, with its imagined monopoly on subjectivity, that keeps us from recognizing them all, our kith and kin. In this sense, I guess Paul Stamets is right to think the mushrooms are bringing us messages from nature, or at least helping us to open up and read them.

  Before this afternoon, I had always assumed access to a spiritual dimension hinged on one’s acceptance of the supernatural—of God, of a Beyond—but now I’m not so sure. The Beyond, whatever it consists of, might not be nearly as far away or inaccessible as we think. Huston Smith, the scholar of religion, once described a spiritually “realized being” as simply a person with “an acute sense of the astonishing mystery of everything.” Faith need not figure. Maybe to be in a garden and feel awe, or wonder, in t
he presence of an astonishing mystery, is nothing more than a recovery of a misplaced perspective, perhaps the child’s-eye view; maybe we regain it by means of a neurochemical change that disables the filters (of convention, of ego) that prevent us in ordinary hours from seeing what is, like those lovely leaves, staring us in the face. I don’t know. But if those dried-up little scraps of fungus taught me anything, it is that there are other, stranger forms of consciousness available to us, and, whatever they mean, their very existence, to quote William James again, “forbid[s] a premature closing of our accounts with reality.”

  Open-minded. And bemushroomed. That was me, now, ready to reopen my own accounts with reality.

  CHAPTER THREE

  HISTORY

  The First Wave

  WHEN THE FEDERAL AUTHORITIES CAME down hard on Timothy Leary in the mid-1960s, hitting him with a thirty-year sentence for attempting to bring a small amount of marijuana over the border at Laredo, Texas, in 1966,* the embattled former psychology professor turned to Marshall McLuhan for some advice. The country was in the throes of a moral panic about LSD, inspired in no small part by Leary’s own promotion of psychedelic drugs as a means of personal and cultural transformation and by his recommendation to America’s youth that they “turn on, tune in, drop out.” Dated and goofy as those words sound to our ears, there was a moment when they were treated as a credible threat to the social order, an invitation to America’s children not only to take mind-altering drugs but to reject the path laid out for them by their parents and their government—including the path taking young men to Vietnam. Also in 1966, Leary was called before a committee of the U.S. Senate to defend his notorious slogan, which he gamely if not very persuasively attempted to do. In the midst of the national storm raging around him—a storm, it should be said, he quite enjoyed—Leary met with Marshall McLuhan over lunch at the Plaza hotel in New York, the LSD guru betting that the media guru might have some tips on how best to handle the public and the press.

  “Dreary Senate hearing and courtrooms are not the platforms for your message, Tim,” McLuhan advised, in a conversation that Leary recounts in Flashbacks, one of his many autobiographies. (Leary would write another one every time legal fees and alimony payments threatened to empty his bank account.) “To dispel fear you must use your public image. You are the basic product endorser.” The product by this point was of course LSD. “Whenever you are photographed, smile. Wave reassuringly. Radiate courage. Never complain or appear angry. It’s okay if you come off as flamboyant and eccentric. You’re a professor after all. But a confident attitude is the best advertisement. You must be known for your smile.”

  Leary took McLuhan’s advice to heart. In virtually all of the many thousands of photographs taken of him from that lunch date forward, Leary made sure to present the gift of his most winning grin to the camera. It didn’t matter if he was coming into or out of a courthouse, addressing a throng of youthful admirers in his love beads and white robes, being jostled into a squad car freshly handcuffed, or perched on the edge of John and Yoko’s bed in a Montreal hotel room, Timothy Leary always managed to summon a bright smile and a cheerful wave for the camera.

  So, ever smiling, the charismatic figure of Timothy Leary looms large over the history of psychedelics in America. Yet it doesn’t take many hours in the library before you begin to wonder if maybe Timothy Leary looms a little too large in that history, or at least in our popular understanding of it. I was hardly alone in assuming that the Harvard Psilocybin Project—launched by Leary in the fall of 1960, immediately after his first life-changing experience with psilocybin in Mexico—represented the beginning of serious academic research into these substances or that Leary’s dismissal from Harvard in 1963 marked the end of that research. But in fact neither proposition is even remotely true.

  Leary played an important role in the modern history of psychedelics, but it’s not at all the pioneering role he wrote for himself. His success in shaping the popular narrative of psychedelics in the 1960s obscures as much as it reveals, creating a kind of reality distortion field that makes it difficult to see everything that came either before or after his big moment onstage.

  In a truer telling of the history, the Harvard Psilocybin Project would appear more like the beginning of the end of what had been a remarkably fertile and promising period of research that unfolded during the previous decade far from Cambridge, in places as far flung as Saskatchewan, Vancouver, California, and England, and, everywhere, with a lot less sound and fury or countercultural baggage. The larger-than-life figure of Leary has also obscured from view the role of a dedicated but little-known group of scientists, therapists, and passionate amateurs who, long before Leary had ever tried psilocybin or LSD, developed the theoretical framework to make sense of these unusual chemicals and devised the therapeutic protocols to put them to use healing people. Many of these researchers eventually watched in dismay as Leary (and his “antics,” as they inevitably referred to his various stunts and pronouncements) ignited what would become a public bonfire of all their hard-won knowledge and experience.

  In telling the modern history of psychedelics, I want to put aside the Leary saga, at least until the crack-up where it properly belongs, to see if we can’t recover some of that knowledge and the experience that produced it without passing it through the light-bending prism of the “Psychedelic Sixties.” In doing so, I’m following in the steps of several of the current generation of psychedelic researchers, who, beginning in the late 1990s, set out to excavate the intellectual ruins of this first flowering of research into LSD and psilocybin and were astounded by what they found.

  Stephen Ross is one such researcher. A psychiatrist specializing in addiction at Bellevue, he directed an NYU trial using psilocybin to treat the existential distress of cancer patients, to which I will return later; since then, he has turned to the treatment of alcoholics with psychedelics, what had been perhaps the single most promising area of clinical research in the 1950s. When several years ago an NYU colleague mentioned to Ross that LSD had once been used to treat thousands of alcoholics in Canada and the United States (and that Bill Wilson, the founder of Alcoholics Anonymous, had sought to introduce LSD therapy into AA in the 1950s), Ross, who was in his thirties at the time, did some research and was “flabbergasted” by all that he—as an expert on the treatment of alcoholism—did not know and hadn’t been told. His own field had a secret history.

  “I felt a little like an archaeologist, unearthing a completely buried body of knowledge. Beginning in the early fifties, psychedelics had been used to treat a whole host of conditions,” including addiction, depression, obsessive-compulsive disorder, schizophrenia, autism, and end-of-life anxiety. “There had been forty thousand research participants and more than a thousand clinical papers! The American Psychiatric Association had whole meetings centered around LSD, this new wonder drug.” In fact, there were six international scientific meetings devoted to psychedelics between 1950 and 1965. “Some of the best minds in psychiatry had seriously studied these compounds in therapeutic models, with government funding.” But after the culture and the psychiatric establishment turned against psychedelics in the mid-1960s, an entire body of knowledge was effectively erased from the field, as if all that research and clinical experience had never happened. “By the time I got to medical school in the 1990s, no one even talked about it.”

  * * *

  • • •

  WHEN LSD BURST onto the psychiatric scene in 1950, the drug’s effects on patients (and researchers, who routinely tried the drug on themselves) were so novel and strange that scientists struggled for the better part of a decade to figure out what these extraordinary experiences were or meant. How, exactly, did this new mind-altering drug fit into the existing paradigms for understanding the mind and the prevailing modes of psychiatry and psychotherapy? A lively debate over these questions went on for more than a decade. What wasn’t known at the time is that beginning in 1
953, the CIA was conducting its own (classified) research into psychedelics and was struggling with similar issues of interpretation and application: Was LSD best regarded as a potential truth serum, or a mind-control agent, or a chemical weapon?

  The world’s very first LSD trip, and the only one undertaken with no prior expectations, was the one Albert Hofmann took in 1943. While it left him uncertain whether he had experienced madness or transcendence, Hofmann immediately sensed the potential importance of this compound for neurology and psychiatry. So Sandoz, the pharmaceutical company for which he worked at the time of his discovery, did something unusual: in effect, it crowd-sourced a worldwide research effort to figure out what in the world Delysid—its brand name for LSD-25—might be good for. Hoping someone somewhere would hit upon a commercial application for its spookily powerful new compound, Sandoz offered to supply, free of charge, however much LSD any researcher requested. The company defined the term “researcher” liberally enough to include any therapist who promised to write up his or her clinical observations. This policy remained more or less unchanged from 1949 to 1966 and was in large part responsible for setting off the first wave of psychedelic research—the one that crashed in 1966, when Sandoz, alarmed at the controversy that had erupted around its experimental drug, abruptly withdrew Delysid from circulation.